The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis

A chondrosarcoma is a common tumor of the soft tissue and bone that has high propensity to metastasize distant organs. Nerve growth factor (NGF) capable promoting progression metastasis several different types tumors although effects NGF in are not confirmed. Here, we found levels matrix metalloproteinase-2 (MMP-2) correlated with stage patients chondrosarcoma. facilitated MMP-2-dependent cellular migration human JJ012 cells while overexpression enhanced lung mouse model promoted MMP-2 synthesis cell by inhibiting miR-423-5p expression through FAK c-Src signaling cascades. appears be worthwhile therapeutic target treatment metastatic